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1.
Label-Free Characterization of Macrophage Polarization Using Raman Spectroscopy.
Int J Mol Sci;
24(1)2023 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36614272
2.
Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood.
Cell Mol Life Sci;
79(1): 40, 2021 Dec 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-34971430
3.
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.
Pharmacol Res;
167: 105556, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33812006
4.
Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.
FASEB J;
33(5): 6140-6153, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30735438
5.
Improved Bioactivity of the Natural Product 5-Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles.
Mol Pharm;
17(3): 810-816, 2020 03 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31967843
6.
Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol.
J Chem Inf Model;
60(3): 1737-1748, 2020 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32045233
7.
Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.
J Nanobiotechnology;
18(1): 73, 2020 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32408877
8.
Correction: Encapsulation of the dual FLAP/mPEGS1 inhibitor BRP187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.
J Nanobiotechnology;
22(1): 77, 2024 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38408973
9.
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms.
ACS Chem Biol;
19(1): 217-229, 2024 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38149598
10.
Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors.
ACS Med Chem Lett;
14(1): 26-34, 2023 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36655121
11.
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators.
Cell Chem Biol;
30(12): 1508-1524.e7, 2023 12 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-37647900
12.
Encapsulation of the Anti-inflammatory Dual FLAP/sEH Inhibitor Diflapolin Improves the Efficiency in Human Whole Blood.
J Pharm Sci;
111(6): 1843-1850, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34756868
13.
Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors.
ChemMedChem;
17(12): e202200137, 2022 06 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35466565
14.
Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201.
J Inflamm Res;
15: 911-925, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35173459
15.
Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase.
Eur J Med Chem;
231: 114167, 2022 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35152061
16.
Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages.
Biochem Pharmacol;
203: 115202, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35932797
17.
Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages.
Biochem Pharmacol;
195: 114825, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34762841
18.
Biocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammation.
Int J Pharm;
601: 120567, 2021 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33812975
19.
Effect of Crystallinity on the Properties of Polycaprolactone Nanoparticles Containing the Dual FLAP/mPEGS-1 Inhibitor BRP-187.
Polymers (Basel);
13(15)2021 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-34372160
20.
From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution.
Acta Pharm Sin B;
11(6): 1629-1647, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-34221873